The opening day of the Beton Ukrainian Cup round of 16 featured Levyi Bereh against Veres at 13:00, followed by the headline meeting between Shakhtar and Dynamo at Arena Lviv at 18:00. Both games were listed for October 27, but the source article did not include their results.

The Ukrainian Premier League (upl.ua) reported the match schedule on Tuesday, October 27. UPL.TV was named as the broadcaster for every tie in the round.

Four fixtures were placed on the October 28 programme: Mayak versus Kharkiv, Chernihiv versus Epitsentr, LNZ versus Metalist, and Polissya versus Novyi Rozdil. The remaining games on October 29 pair Zorya with Kryvbas and Karpaty with Oleksandriya.